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논문분류	춘계학술대회 초록집
제목	SLOPE OF WAIST-HIP RATIO IS ASSOCIATED WITH RISK OF INCIDENT CHRONIC KIDNEY DISEASE
저자	Shin Chan Kang, Jee Young Lee, Geun Woo Ryu, Hyung Woo Kim, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Beom-seok Kim
출판정보	2020; 2020(1):
키워드	Chronic kidney disease \| Obesity \| Waist-hip ratio
초록	Obesity and chronic kidney disease (CKD) are both major global health problem and obesity is a risk factor for CKD.1 Especially, abdominal obesity is an important predictor of CKD and among indices of obesity, waist-hip ratio (WHR) is known to predict CKD better than other indices such as body mass index or body weight.2,3 However, whether reduction of abdominal obesity can decrease risk of CKD is not yet revealed. Therefore, whether slope of WHR is associated with risk of CKD was investigated in general population. Data were retrieved from 10,030 participants in Korean Genome and Epidemiology Study_Ansung-Ansan cohort. After exclusion, a total of 3,746 participants with abdominal obesity based on WHR were included in final analysis. The participants were divided into tertiles according to annualized slope of WHR derived from linear regression and those with estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m2 at least two consecutive tests were regarded to have CKD. During mean follow-up of 11.8 years, incident CKD occurred in 208 (7.6%) participants. There were 75 (6.0%), 69 (5.5%) and 64 (5.1%) incident CKD in T1, T2 and T3 and the corresponding age and sex-adjusted incident rate were 5.1, 6.2 and 5.6 per 1,000 person-years, respectively. In multivariable Cox model after adjustment of confounding factors, participants in groups with lowest slope had lower risk of incident CKD than those in groups with highest slope [hazard ratio (HR) 0.62, 95% confidence interval (CI) 0.44-0.88, p=0.027]. When CKD was defined considering both eGFR and proteinuria, the results were consistent (HR 0.68, 95% CI 0.52-0.91). Slope of WHR was associated with risk of incident CKD in general population. Reduction of abdominal obesity may reduce occurrence of CKD.
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