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논문분류	춘계학술대회 초록집
제목	Gender differences in interconnections between the serum level of interleukin-18 and the renal function in patients with diabetes and early CKD
저자	Ivan Pchelin, Alexander Shishkin
출판정보	2020; 2020(1):
키워드	diabetes \| nephropathy \| CKD \| interleukin-18 \| inflammation
초록	Interleukin-18 (IL-18) is involved in the pathogenesis of diabetic nephropathy. Experimental studies have also shown that female sex hormones are necessary for realization of some of the effects mediated by IL-18. In this study, we assessed serum levels of IL-18 and their clinical correlates in men and women with early diabetes-related CKD. We investigated 65 patients with type 2 diabetes and CKD stages 1-3 (42 women and 23 men). eGFR was calculated using CKD-EPI formula. In addition to routine clinical tests, we assessed serum level of IL-18. Mann-Whitney U-test and Spearmen’s correlation coefficient (rs) were used for statistical analysis. The groups were comparable with regard to age, anthropometric data and parameters of renal function. Mean levels of IL-18 were similar in men and women: 278±20 and 246±17 pg/ml (p=0.096), respectively. A significant correlation between the levels of IL-18 and eGFR was observed only in women (rs= -0.354, p=0.024), but not in men (rs= 0.216, p=0.347). In contrast, a significant correlation between the concentration of IL-18 and the level of albuminuria was observed in men (rs= 0.480, p=0.032), but not in women (rs= -0.087, p=0.605). In both groups, the concentration of IL-18 was not interconnected with age, body mass index, and parameters of lipid and сarbohydrate metabolism. The results of the study suggest that men and women with type 2 diabetes and early CKD are characterized by different interrelationships between serum IL-18 and eGFR, as well as serum IL-18 and albuminuria. This may result from gender-specific effects of IL-18 and requires further investigation.
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