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논문분류	춘계학술대회 초록집
제목	Molecular Interaction of IL-10 and IL-25 in Lupus Nephritis
저자	Rian Ka Praja, Reny Rosalina
출판정보	2020; 2020(1):
키워드	GATA3 \| IL-10 \| IL-25 \| lupus nephritis \| systemic lupus erythematosus
초록	Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disorder associated with lupus nephritis marked by overexpression of some cytokines. Recently, IL-10 has been reported to be associated with lupus nephritis and can be used as a biomarker of this disease. Previous study reported elevated IL-25 expression was correlated with the severity of SLE with lupus nephritis. Therefore, these both IL-10 and IL-25 are thought to be involved in the pathogenesis of SLE with lupus nephritis. However, there is no report related to their interaction in driving lupus nephritis. We hypothesized that IL-10 and IL-25 are interacted each other in lupus nephritis. The aim of this study was to predict molecular interaction between IL-10 and IL-25 in lupus nephritis by using STITCH analysis. STITCH v.5.0, online bioinformatics software, was employed for this prediction of molecular interaction. We set “IL10” and “IL25” as keywords used for bioinformatics analysis. In the part of organism type, Homo sapiens was selected to predict protein-protein interactions in human and followed by selecting the variant of molecules based on keywords used. After completing all steps, STITCH generated prediction of molecular interaction between IL-10 and IL-25. Based on the STITCH analysis, IL-10 and IL-25 were connected with some molecules such as IL-4 and GATA Binding Protein 3 (GATA3). After reducing the number of interactors, IL-10 and IL-25 were directly associated with GATA3. Interaction score of IL-10 – GATA3 and IL-25 – GATA3 was 0.989 and 0.885, respectively. From this bioinformatics study, it can be conclude that IL-10 and IL-25 are associated with GATA3. However, some laboratory experiments are needed to prove this interaction and their role in lupus nephritis.
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