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논문분류	춘계학술대회 초록집
제목	COMPARISON OF BLOOD PRESSURE REDUCTION EFFECT OF COMBINATION VERSUS SINGLE ANTIHYPERTENSIVE THERAPY ON PROLANIS PARTICIPANTS IN KEDUNGADEM PUBLIC HEALTH CENTER, INDONESIA
저자	Rori Syahnidep, Endah Setyaningsih
출판정보	2020; 2020(1):
키워드	PROLANIS \| Hypertension \| Antihypertensive Drug
초록	PROLANIS is a health service system for patients with chronic diseases. Activities consist in this system are medical education, health status monitoring and treatment, home visit, and group activity. The aim of our study is to compare systolic (SBP) and diastolic (DBP) blood pressure reduction in PROLANIS participants who received combination vs single antihypertensive drug and educated to modify their lifestyle in Kedungadem Public Health Center, Indonesia. We conducted a 3-months (July – October 2019) prospective study on PROLANIS participants who diagnosed with hypertension. We divided participants into two group based on drugs they previously received (combination or single). Demographic data, SBP and DBP were recorded. Statistical analyses were performed to measure mean reduction blood pressure for each group and to compare the mean reduction of blood pressure between the two groups. Total 44 patients proceed to statistical analysis. We got 22 patients have used combination therapy, and others single therapy. Our analysis revealed that combination therapy significantly reduced SBP (159 to 139 mmHg) and DBP (90 mmHg to 81 mmHg) (p < 0.000 and < 0.001, respectively). Single therapy was also found significantly reduced SBP (149 to 140 mmHg) and DBP (88 to 82 mmHg) (p = 0.003 and p = 0.005, respectively). Further analysis between two groups showed that combination therapy is significantly better in reducing SBP than single therapy (20 mmHg vs 9 mmHg, p = 0.025) but not significantly different in reducing DBP (9 vs 6 mmHg, p = 0.381). Combination therapy is more effective in reducing SBP but not DBP on PROLANIS participants in Kedungadem Public Health Center, Indonesia.
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