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논문분류	춘계학술대회 초록집
제목	Association between Genetic Variations of Angiotensin I-Converting Enzyme (ACE) Gene on Blood Pressure in High School Teachers in Yogyakarta, Indonesia
저자	Emy Huriyati, Ainun Nisa, Aulia 'Afifah
출판정보	2020; 2020(1):
키워드	ACE gene \| blood pressure \| hypertension \| high school teacher
초록	Teaching is considered to be a significantly stressful occupation. The occurrence of occupational stress has been suggested as an important factor in the development of various causes of morbidity and mortality. Teachers’ workload and limit access to being physically active can trigger the occurrence of hypertension. Hypertension is caused by the presence of risk factors; one of them is genetic factors. The aim of this study is to determine the association between genetic variations of the ACE gene on blood pressure in high school teachers in Yogyakarta. A cross-sectional study design involving 89 high school teachers in Yogyakarta by cluster sampling. The inclusion criteria of participants’ selection were 18-55 years old and willing to be subject of the study by completing the informed consent. The exclusion criteria were pregnant, breastfeed, and under medication of cardiovascular disease. Body weight, height, body mass index, blood pressure, and waist circumference of the subjects were measured. Genetic variations of the ACE gene were measured using PCR and electrophoresis procedures. The data were analyzed statistically used chi-square and logistic regression Backward Stepwise (Likelihood Ratio) method with the SPSS program. The subjects were dominated by female (73.03%) and aged ≥40 y.o. (71.91%). There were three genotypes of genetic variation of the ACE gene in 89 subjects, II, ID, and DD. The chi-square analysis results show no significant association between genetic variation of the ACE gene on blood pressure (p = 0.153). The logistic regression analysis results showed a significant association between gender on blood pressure (p = 0.00; 95% CI 1.476-2.598). There is no difference in genetic variations of ACE gene II, ID, and DD genotype on blood pressure. Therefore, II genotype tends to 2.3 times can affect blood pressure and DD genotype tends to 1.5 times can affect blood pressure compared with ID genotype.
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