대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Evaluation of Synergestic Antiurolithiatic Effect of Tribulus terrestris Fruit extract with Selected Indian Medicinal Plants.
저자	SOURABH JAIN
출판정보	2020; 2020(1):
키워드	Gokhru \| Stone \| Herbal
초록	Tribulus terrestris in one of leading medicinal plant which is used in treatment of varius kidney disorder including stone by various ayurvedic practitioner. Based on the literature survey, two more medicinal plants Terminalia chebula and Tinsopora cordifolia were selected, which were claimed in traditional medicine to dissolve renal stones. So the present study was undertaken to investigate the combine synergestic antiurolithiatic effect of Tribulus terrestris Linn (Gokhru) with aqueous extract of Terminalia chebula and Tinsopora cordifolia. Renal calculi were induced in rats by administration of 0.75% Ethylene glycol in drinking water and co‑treated orally with standard drug, Cystone (750 mg/kg) (Group I), with combined aqueous extracts (200 mg of Tribulus terrestris Aq. Extract with 100 mg Terminalia chebula and Tinsopora cordifolia Aq. extract) (Group II) in doses of 500 mg/kg and with aqueous extract of Tribulus terrestris alone (Group III) in doses of 500 mg/kg for 21 days. Weekly body weights were recorded. On day 22, urolithiasis was confrmed by assessing the urinary parameters (urine volume, pH, uric acid etc serum biochemical parameters , oxidative stress parameters and histology of kidney. Treatment with Combined extracts (Group II) attenuated the EG‑induced decrease significantly in body weight and elevation in urinary parameters and serum biochemical parameters as compared to single extract of Gokhru (Group III). Combine extract treatment also reversed EG‑induced decrease in urine volume, pH, magnesium and creatinine clearance, oxidative and histological damages in kidneys. Results were comparable to standard drug, Cystone. Results indicated that EG administration caused renal calculi formation which is prevented by treatment with combined extracts. Combined aqueous extracts of Tribulus terrestris with Terminalia chebula and Tinsopora cordifolia showed preventive effect against renal calculi formation and validates its ethnomedicinal use in urinary disorders. It further supports its therapeutic potential for the treatment of urinary calculi.
원문(PDF)	PDF 원문보기

목록

위로가기