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논문분류	춘계학술대회 초록집
제목	Formulation and evaluation of Polyherbal formulation for kidney protection
저자	Nidhi Dangi
출판정보	2020; 2020(1):
키워드	Polyherbal formulation \| Tribulus Terrestris \| Kidney
초록	The objectives of the study were to assess the potential of herbal formulation made up of Tribulus Terrestris, Wedelia chinensis leaves and Vitis venifera in possessing activity like nephroprotectivity and diuretic activity. Different concentrations of Polyherbal formulations ( 250 and 500 mg/kg), furosemide (10 mg/kg) and vehicle were orally administered to rat (n = 6 animals per group) and their urine output was collected after 24h. The Urinary output, Osmolarity, pH, Na+, K+ and Cl− concentrations of urine were estimated. In Vitro Nephroprotective activity was evaluated using MTT cytotoxicity assay using mammalian cell culture. The results of the nephroprotective activities showed that the formulation mixture of herbs is an excellent source of organ stimulator with high therapeutical importance. There significant increase in Na+, K+, Cl− excretion, caused alkalinization of urine, showed strong Diuretic index, saluretic index and Natruretic index. The hepatoprotective properties make this formulation a unique one focusing on kidney diseases. These finding strongly suggests that the Polyherbal formulations have a good diuretic activity on rats in the above experimental model.
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