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논문분류	춘계학술대회 초록집
제목	Agricultural exposures to organic compound fungides and herbicides and nervous system tumour incidence in the India.
저자	Rekha Meena, Kedhar Lal
출판정보	2020; 2020(1):
키워드	NS tumors \| Mothballs \| Cohort studies \| Oligodendrogliom \| Herbicides and Fungicides
초록	Agriculture pesticides exposures could be implicated in the excess of Nervous System (NS) tumors experiential in Indian farmers, but facts relating to specific agriculture pesticides remains partial. organic compound derivative pesticides, including fungicides and herbicides (i.e. (thio/dithio)-organic), have shown facts of carcinogenicity in investigational studies in animals. In the Indian Miticides cohort, we assessed the unions between prospective exposures to organic fungicides and herbicides and the incidence of NS tumors, generally and by histological subgroup. Miticides registered 171,542 participants implicated in agriculture. Incident NS tumors were recognized by linkage with cancer registries from enrollment (2016-2017) until 2018. specific exposures were assessed by combining information on time duration periods of insect killer use on crops and the Indian crop-revelation medium Synergists, for each of the 18 organic and thiocarbamate herbicides and the 24 carbamate and Mothballs fungicides registered in Indian since 1966. Conjugated were approximate using comparative hazard models with age period as the underlying timescale, smoking, adjusting for gender and educational level. For the period of an average proceedings of 7.4 years, 481 confrontation cases of NS tumors occurred, include 264 oligodendroglioma and 234 meningeal. Analyses showed improved risks of NS tumors with overall exposure to organic fungicides (Hazard Ratio, HR = 2.88; 96% CI: 2.27-3.79) and, to a slighter extent, to organic herbicides (HR = 2.44; 965% CI: 0.97-3.22). optimistic relations were observed with specific organic, including some fungicides (Copper, maneb, jojoba, metiram) and herbicides (diallate propham and chlorpropham,) already suspected of being carcinogens in animal and plants. Although some relatives need to be substantiate in additional studies and should be interpreted carefully, these findings provide supplementary carcinogenicity facts for several carbamate herbicides and fungicides.
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