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논문분류	춘계학술대회 초록집
제목	Potential of Therapeutic microRNA miR-21 and miR-29 for the treatment of renal fibrosis and chronic kidney disease: Systematic Review
저자	Bastomy Eka Rezkita
출판정보	2020; 2020(1):
키워드	microRNA \| miR21 \| miR29 \| renal fibrosis
초록	The aim of this review is to know the potential of therapeutic microRNA miR-21 and miR-29 for the treatment of renal fibrosis and chronic kidney disease The method used four search engines that continued by 4 inclusions and 3 exclusion criteria to be analyzed. Our review was arranged by 60 Journals selected by this method. Several study about the role of MicroRNA miR-21 and miR-29 as Regulators of Cellular function in fibrotic formation have been colected. Study showed that antifibrotic effects have been reported for all of the miR-21 and miR-29 family member. Streptozotocin-induced diabetic miR-21 and miR-29 transgenic mice showed 164 improved renal function with less glomerular fibrosis and inflammation, and better podocyte 165 viability compared to diabetic WT mice. miR-21 and miR-29 have important role in decreasing fibrotic formation to prevent chronic kidney disease
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