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논문분류	춘계학술대회 초록집
제목	Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide intoxication
저자	AYOUNG CHO, Ji Hye Lim, Ju Hwan Oh, Kwang Young Lee, In O Sun
출판정보	2021; 2021(1):
키워드
초록	Objective: From 2008 to 2019, 172 patients admitted to our hospital after GlySH poisoning. We evaluated the incidence, clinical characteristics, and severity of AKI based on the RIFLE classification. Methods: The patients included 117 men and 55 women with a mean age of 59 years (range, 22-101 years). Of the 172 patients, 68 had AKI during admission period. The incidence of AKI was 39.5%; of which, 21.5%, 11.0% and 6.9% were classified as Risk, Injury and Failure, respectively. Compared with patients in the non-AKI group, patients in the AKI group had lower serum bicarbonate level (17.9 ± 5.1 mmol/L vs. 21.0 ± 3.6 mmol/L, p<0.01) and higher serum total bilirubin levels (0.83 ± 0.70 vs. 0.64 ± 0.40 mg/dL, p=0.034). In comparison with patients of non-AKI group, patients with AKI experienced intubation (42.6% vs. 4.8%, p<0.001) and intensive care unit care (61.8 % vs. 23.2 %, p<0.001) more frequently. The mortality rate was higher in AKI group than in non-AKI group (19.1 % vs. 1.0 %, p<0.001). In multiple logistic regression analysis, hyperbilirubinemia and hypotension on admission were significant predictors of AKI. Results: Serum total bilirubin concentration and blood pressure on admission is useful predictors for the development of AKI in patients with GlySH intoxication. Conclusions: Objective: This study aimed to investigate the clinical characteristics of acute kidney injury (AKI) in patients with glyphosate surfactant herbicide (GlySH) intoxication. Methods: From 2008 to 2019, 172 patients admitted to our hospital after GlySH poisoning. We evaluated the incidence, clinical characteristics, and severity of AKI based on the RIFLE classification. Results: The patients included 117 men and 55 women with a mean age of 59 years (range, 22-101 years). Of the 172 patients, 68 had AKI during admission period. The incidence of AKI was 39.5%; of which, 21.5%, 11.0% and 6.9% were classified as Risk, Injury and Failure, respectively. Compared with patients in the non-AKI group, patients in the AKI group had lower serum bicarbonate level (17.9 ± 5.1 mmol/L vs. 21.0 ± 3.6 mmol/L, p<0.01) and higher serum total bilirubin levels (0.83 ± 0.70 vs. 0.64 ± 0.40 mg/dL, p=0.034). In comparison with patients of non-AKI group, patients with AKI experienced intubation (42.6% vs. 4.8%, p<0.001) and intensive care unit care (61.8 % vs. 23.2 %, p<0.001) more frequently. The mortality rate was higher in AKI group than in non-AKI group (19.1 % vs. 1.0 %, p<0.001). In multiple logistic regression analysis, hyperbilirubinemia and hypotension on admission were significant predictors of AKI. Conclusions: Serum total bilirubin concentration and blood pressure on admission is useful predictors for the development of AKI in patients with GlySH intoxication.
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