대한신장학회

논문분류	춘계학술대회 초록집
제목	1,25-dihydroxyvitamin D deficiency is an independent predictor of cardiac valve calcification in patients with chronic kidney disease
저자	Suji Kim, Byung Min Ye, Min Jeong Kim, Seo Rin Kim, Il Young Kim, Dong Won Lee, Soo Bong Lee
출판정보	2021; 2021(1):
키워드
초록	Objective: A total of 513 patients with pre-dialysis CKD were included in this cross-sectional study. Aortic valve calcification (AVC) and mitral valve calcification (MVC) were assessed using two-dimensional echocardiography. The associations of AVC and MVC with baseline variables were investigated by logistic regression analyses. Methods: In multivariable analysis, serum 1,25(OH)2D level was an independent predictor of AVC (odds ratio [OR]: 0.87, P < 0.001) and MVC (OR: 0.92, P < 0.001). Besides, age, diabetes, coronary heart disease, calcium × phosphate product, intact parathyroid hormone were independent predictors of AVC and MVC. Systolic blood pressure was an independent predictor of the only AVC. Receiver-operating characteristic (ROC) curve analysis showed that the best cutoff values of serum 1,25(OH)2D level for predicting AVC and MVC were ≤ 12.5 and ≤ 11.9 pg/dl, respectively. Results: Serum 1,25(OH)2D deficiency were independent predictors of AVC and MVC in patients with CKD. ROC curve analysis suggested that serum 1,25(OH)2D could be a potential biomarker of AVC and MVC in these patients. Conclusions: Objective: Cardiac valve calcification is highly prevalent in patients with chronic kidney disease (CKD). Low vitamin D level is known to be associated with vascular calcification in CKD. However, the association of vitamin D with cardiac valve calcification is unknown. We hypothesized that serum 1,25 dihydroxyvitamin D [1,25(OH)2D], an active form of vitamin D, is an independent predictor of cardiac valve calcification in patients with CKD. Methods: A total of 513 patients with pre-dialysis CKD were included in this cross-sectional study. Aortic valve calcification (AVC) and mitral valve calcification (MVC) were assessed using two-dimensional echocardiography. The associations of AVC and MVC with baseline variables were investigated by logistic regression analyses. Results: In multivariable analysis, serum 1,25(OH)2D level was an independent predictor of AVC (odds ratio [OR]: 0.87, P < 0.001) and MVC (OR: 0.92, P < 0.001). Besides, age, diabetes, coronary heart disease, calcium × phosphate product, intact parathyroid hormone were independent predictors of AVC and MVC. Systolic blood pressure was an independent predictor of the only AVC. Receiver-operating characteristic (ROC) curve analysis showed that the best cutoff values of serum 1,25(OH)2D level for predicting AVC and MVC were ≤ 12.5 and ≤ 11.9 pg/dl, respectively. Conclusions: Serum 1,25(OH)2D deficiency were independent predictors of AVC and MVC in patients with CKD. ROC curve analysis suggested that serum 1,25(OH)2D could be a potential biomarker of AVC and MVC in these patients.
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정