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논문분류	춘계학술대회 초록집
제목	Effect of Water Intake and Water Balance on All-cause and Cardiovascular Mortality based on the Nation-Wide Population Study
저자	Seonmi Hwang, Yaerim Kim, Jeonghwan Lee, Jae Yoon Park, Kyung Don Yoo, Yong Chul Kim, Yun Kyu Oh, Dong Ki Kim, Jung Pyo Lee
출판정보	2021; 2021(1):
키워드
초록	Objective: We conducted a prospective cohort study using 1999 to 2015 data from the National Health and Nutrition Examination Survey. A total of 39,039 patients aged over 19 years who had water consumption data using 24-hour dietary recall were enrolled. Participants' hydration status was measured by bioelectical impedance analysis (BIA). The all-cause mortality were calculated using the multivariable Cox model adjusting for comorbidities, body mass index, glomerular filtration rate, serum albumin, and total cholesterol representing nutritional status. Methods: In weighted multivariable Cox models, compared to people with lowest quartile of water intake, the adjusted hazard ratios (aHRs) for all-cause mortality in people with other quartiles 2nd, 3rd, and 4th were 0.83 (95% confidence interval [CI], 0.75-0.91), 0.76 (95% CI, 0.68-0.84) and 0.80 (95% CI, 0.72-0.88), respectively. Restricted cubic spline regression also found a U-shaped relationship between total body water and all-cause mortality. In the correlation analysis, as the water intake increased, the total body water amount measured by BIA increased. Additionally, participants showed lower mortality rates as the total amount of water in the body was higher (1st vs.2nd aHR 0.928 [95% CI, 0.622-1.384] and 1st vs. 3rd aHR 0.542 [95% CI, 0.315-0.933]). Results: In the general population, which is not in a disease state, too little water in the body and water intake are associated with increased mortality. It is important to maintain adequate hydration status through adequate water consumption. Conclusions: Objective: The water balance consists of loss of water and intake of water. Healthy people maintain a good physiological water balance in their daily lives. The aim of this study was to investigate whether fluid intake is independently correlated with all-cause mortality among the general US adult population. In addition, we evaluated the relationship between fluid intake and the participants' hydration status. Methods: We conducted a prospective cohort study using 1999 to 2015 data from the National Health and Nutrition Examination Survey. A total of 39,039 patients aged over 19 years who had water consumption data using 24-hour dietary recall were enrolled. Participants' hydration status was measured by bioelectical impedance analysis (BIA). The all-cause mortality were calculated using the multivariable Cox model adjusting for comorbidities, body mass index, glomerular filtration rate, serum albumin, and total cholesterol representing nutritional status. Results: In weighted multivariable Cox models, compared to people with lowest quartile of water intake, the adjusted hazard ratios (aHRs) for all-cause mortality in people with other quartiles 2nd, 3rd, and 4th were 0.83 (95% confidence interval [CI], 0.75-0.91), 0.76 (95% CI, 0.68-0.84) and 0.80 (95% CI, 0.72-0.88), respectively. Restricted cubic spline regression also found a U-shaped relationship between total body water and all-cause mortality. In the correlation analysis, as the water intake increased, the total body water amount measured by BIA increased. Additionally, participants showed lower mortality rates as the total amount of water in the body was higher (1st vs.2nd aHR 0.928 [95% CI, 0.622-1.384] and 1st vs. 3rd aHR 0.542 [95% CI, 0.315-0.933]). Conclusions: In the general population, which is not in a disease state, too little water in the body and water intake are associated with increased mortality. It is important to maintain adequate hydration status through adequate water consumption.
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