대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	A journey for diagnosis of hyponatremia in metastatic epithelioid mesothelioma
저자	Wonkyo Yi,Kyoung Min Kim,Kyung Pyo Kang
출판정보	2022; 2022(1):
키워드
초록	Case Study: Malignant mesothelioma stems from a single layer of mesothelial cells that line the pleural cavity, peritoneal cavity, or pericardium. Pathologic types of malignant mesothelioma include epithelioid, sarcomatoid, or biphasic (mixed). The syndrome of inappropriate antidiuretic hormone (SIADH), characterized by abnormally elevated levels of antidiuretic hormone (ADH), leads to impairment of free water excretion and results in significant electrolyte abnormalities, such as hyponatremia. Here, we report a case of a symptomatic hyponatremia patient who was diagnosed with metastatic epithelioid mesothelioma. A 71-year-old male was presented to our emergency department because of general weakness. He was diagnosed with adenocarcinoma of the lung 14 months ago in past medical history. Two months ago, he was diagnosed with metastatic epithelioid mesothelioma during follow-up surveillance of lung cancer. He was admitted for supportive care for general weakness. On the second hospital day, the newly developed hyponatremia of 123 mmol/L was checked. Serum osmolarity was 260 mOsm/Kg and spot urine sodium concentration 115 mmol/L, suggesting SIADH concerning his malignant epithelioid mesothelioma. We have confirmed by positive ADH staining in metastatic epithelioid mesothelioma. The correlation between various types of malignancy and SIADH as a cause of hyponatremia is well established. Such clinical settings are common for cancer patients with poor oral intake and multiple medications, leading to hyponatremia and inappropriate secretion of antidiuretic hormone. Clinicians need to suspect that relatively rare malignancy, e.g., malignant mesothelioma, can function as an ectopic source of ADH, possibly causing SIADH, and promptly take diagnostic and therapeutic measures.
원문(PDF)	PDF 원문보기

목록

위로가기