대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Effects of zinc oxide nanoparticles on oxidative stress and renal function in fat-fed and streptozotocin-treated rats
저자	Pardeep Kumar,Sagar Lavenia
출판정보	2022; 2022(1):
키워드
초록	Objectives: The present study investigated the impact of zinc oxide nanoparticles (ZnONPs) on serum parameters of renal function, on oxidative stress markers (malondialdehyde [MDA] and 8-isoprostane), and on expression level of insulin receptor, glucose transporter 2 (GLUT2), glucokinase genes and heat-shock proteins (HSPs) in rats. Methods: Male Wistar rats (n=64, 10 weeks old) were divided into four groups. Group 1 received a standard diet (12% of calories as fat). Group 2 received a standard diet, plus ZnONPs; received a single daily oral dose of ZnONPs of 100 mg/kg in suspension. Group 3 received a high-fat diet (40% of calories as fat) for 2 weeks, and was then injected with streptozotocin (STZ) on day 14 (STZ, 40 mg/kg intraperitoneally). Group 4 was treated in the same way as group 3 (HFD/STZ), but was supplemented with ZnONPs 100mg /kg/body weight/day. Oxidative stress in the kidneys of diabetic rats was evidenced by an elevation in levels of MDA and 8-isoprostane. Protein concentrations of insulin receptor, GLUT2, glucokinase genes and heat-shock (HSP60 and HSP70) in renal tissue were determined by Western blot analyses. Results: ZnONPs supplementation lowered kidney concentrations of MDA, 8-isoprostane levels, serum urea-N, and creatinine, and reduced the severity of renal damage in the STZ-treated group (i.e., the diabetes-induced group). The expression of insulin receptor, GLUT-2 , glucokinase genes and HSPs was lower in the STZ group that received ZnONPs than in the group that did not. No significant effect of ZnONPs supplementation was detected in regard to the overall measured parameters in the control group. Conclusions: This study supported the efficacy of ZnONPs in reducing renal risk factors and impairment because of diabetes and act as potent antidiabetic agent.
원문(PDF)	PDF 원문보기

목록

위로가기