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논문분류	춘계학술대회 초록집
제목	AKI and Gut Dysbiosis
저자	Jihyun Yang
출판정보	2022; 2022(1):
키워드
초록	Acute kidney injury (AKI) is defined by a rapid deterioration in serum creatinine, and/or decrease in urine output. It is more appropriate to recognize it as a very complex clinical syndrome rather than a single disease. AKI contributes to not only increase short-term mortality and morbidities but also long-term sequels including chronic kidney disease progression. It has been known that trillions of bacteria are living in the intestine within symbiosis, which means a well-balanced condition in a healthy state. Dysbiosis means an imbalance of the microbiome with gut barrier disruption and immunological alteration. Gut dysbiosis in various diseases has been studied including diabetes, obesity, allergic disease, rheumatologic disease, even in cancer, and more. We focused on kidney disease. In our previous study, we demonstrated an intriguing bidirectional relationship between the kidney and the intestine during AKI. Gut dysbiosis is a consequence of AKI but it is an important modifier determining the post-AKI outcome through immune modulatory effect. Using germ-free mice with fecal microbiome transplantation, we showed that AKI-related dysbiosis augmented AKI severity. At the same time manipulating the microbiome using 2 strategies: total depletion of the microbiome using mixed antibiotics, and oral probiotic supplements would also attenuate the AKI. This suggests that intestinal microbiota might provide a novel therapeutic target in human AKI. It would be necessary that future investigation of the AKI and dysbiosis focus on more detail about the microbiome, various causes of AKI, interaction with the environment and treatment response in the human study.
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