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논문분류	춘계학술대회 초록집
제목	Using of a retrograde reperfusion technique to reduce ischemic-reperfusion injury of kidney graft: a single center experience
저자	Gani Kuttymuratov
출판정보	2023; 2023(1):
키워드
초록	Objectives: Ischemic-reperfusion injury (IRI) of the kidney transplant remains a serious problem in clinical transplantology. IRI occurs immediately after graft reperfusion and can cause dysfunction of the transplanted organ. Methods: In total, we performed 11 kidney transplantations from a living donor using retrograde graft reperfusion. After removal and perfusion of the donor kidney with HTK solution, the graft was implanted into the recipient. After applying the venous anastomosis, a partial arterial anastomosis was applied, leaving a small hole in the area of the anastomosis. The arterial vessel of the recipient was clamped.Venous blood was released through the graft. Within 5-10 minutes, there was a release of blood from thearterial orifice, from where the analysis of venous blood for gases was taken. Then the arterial blood flow was started after the hermetic end of the arterial anastomosis. Blood perfusate from the kidney artery was collected for blood gas analysis. Creatinine and urea were analyzed on the 3th and 10th days after surgery and compared with initial parameters. Immunosuppression was a three-component: CNI + MMF + Steroid with Basiliximab induction. Results: In all cases, the graft function was satisfactory. Significantly changes serum creatinine and urea in posttransplantation period compared control group. Normalization of serum creatinine and urea levels was observed on average on the 2-3th days after surgery. There were no indications for diagnostic biopsy of a kidney graft. Conclusions: The results of the initial experience of kidney transplantation using retrograde reperfusion technique show an improvement in the function of the kidney transplant in early postoperative period.In the future, an increase in the cohort of patients is required to study the effect of retrograde reperfusion.
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