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논문분류	춘계학술대회 초록집
제목	Improvement of left ventricular diastolic function after kidney transplantation
저자	Eun Hee Park
출판정보	2023; 2023(1):
키워드
초록	Objectives: Left ventricular (LV) diastolic dysfunction is frequently observed in patient with end-stage renal disease (ESRD), and has been known as a significant risk factor for cardiovascular events in these patients. We hypothesized that the ratio of early diastolic peak mitral flow velocity to early mitral annulus velocity (E/E`), widely used non-invasive index of LV diastolic dysfunction, would improve following kidney transplantation (KT). Methods: 192 KT recipients who underwent echocardiography (TTE) before KT and 2-year after KT were included this analysis. 137 ESRD patients on dialysis waiting for deceased donor were also included as a control. Linear mixed-effect models with random intercept were used to assess the KT by time interaction on E/E`. Multiple linear regression analysis was used to identify the factors related to change of E/E`. Results: The mean duration between two TTE were 816 days for KT recipients and 827 days for control. Mean E/E` significantly decreased in KT recipients (10.9 to 9.8, P = 0.002) whereas did not in control (11.7 to 11.9, P = 0.605). The between-group difference of E/E was -1.18 (95% CI = -2.25 to -0.12, P = 0.029) favoring KT recipients. In multiple linear regression, KT (standardized beta [SB] = -0.140, P = 0.015), beta blocker (BB) at enroll (SB = -0.143, P = 0.014) and BB at 2-year (SB = 0.199, P = 0.001) were significant predictors for change of E/E`. Conclusions: LV diastolic function may be successfully improved after KT compared to ESRD patients on waiting list. Further studies for understanding myocardial pathophysiology after KT may be helpful for improving survival of patients with chronic kidney disease.
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