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논문분류	춘계학술대회 초록집
제목	Diagnostic and prognostic roles of CRP, procalcitonin, and presepsin in acute kidney injury patients initiating CRRT
저자	Suyeon Han
출판정보	2023; 2023(1):
키워드
초록	Objectives: For high mortality rate of severe AKI patients initiating continuous renal replacement therapy (CRRT), diagnosing and predicting prognosis is very essential. However, with reduced renal function, biomarkers to diagnose and predict prognosis were not fully understood. This study is about CRRT initiating patients diagnosing sepsis and predicting prognosis. Methods: The study was a single center, retrospective study of patients initiating CRRT, which measured C-reactive protein (CRP), presepsin, and procalcitonin in the blood. Sepsis and non-sepsis groups were divided according to SEPSIS-3 criteria. Total of 127 patients and 90 patients were sepsis while 37 patients were non-sepsis. ROC curve was drawn to diagnose sepsis with CRP, presepsin, and procalcitonin. Cox regression was performed to determine the association between biomarkers and survival. Results: In the patients initiating CRRT, CRP and procalcitonin were superior diagnosing sepsis to presepsin. Presepsin was closely related to the eGFR (r=-0.251, p=0.004). The biomarkers (CRP, procalcitonin, and presepsin) were evaluated for prognostic marker in the patients initiating CRRT with sepsis. Procalcitonin over 3ng/mL is associated with higher all-cause mortality by drawing Kaplan-Meier curve(log-rank test p=0.017). In addition, procalcitonin over 3ng/mL is also associated with higher mortality according to univariate and multivariate cox proportional hazard model analysis. Higher lactic acid, SOFA score, eGFR and lower albumin have prognostic value to predict mortality in the patients initiating CRRT with sepsis. Conclusions: Among CRP, procalcitonin, and presepsin, procalcitonin is a significant factor in predicting the survival of patients initiating CRRT with septic acute kidney injury.
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