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논문분류	춘계학술대회 초록집
제목	Association between alcohol intake and measure of incident chronic kidney disease in the elderly: a korean nationwide population-based cohort study
저자	In O Sun
출판정보	2023; 2023(1):
키워드
초록	Objectives: The relationship between alcohol consumption and chronic kidney disease (CKD) was conflicting. Furthermore, there are few reports of association between alcohol consumption and risk of CKD in the elderly. We investigated the influence of alcohol intake on the development of CKD in older adults. Methods: Adults aged ≥65 years who had an estimated glomerular filtration ratio (eGFR) > 60 mL/min/1.73 m2 and normal proteinuria in an initial health check-up were recruited. Alcohol consumption was assessed by average alcohol intake (g/day) based on self-questionnaires and categorized into non-, mild (<15 g/day), moderate (15-30 g/day), and heavy (≥ 30 g/day) groups. The primary outcome was new-onset CKD, defined as eGFR <60 mL/min/1.73m2. Results: In a total of 122,319 subjects, the number of subjects in the non, mild, moderate, and heavy drinker was 99,091 (81.0%), 14,842 (12.1%), 4,257 (3.5%), and 4,139 (3.4%), respectively. During a follow-up period, CKD was recognized in 19,796 (19.98%), 4,636 (31.24%), 1,696 (39.84%) and 1,695 (40.95%) non, mild, moderate, and heavy groups. Compared with non-drinker, the multivariable-adjusted hazard ratios (95% confidence interval) for CKD risk were 0.90 (0.860.94, P <0.001) for mild, 0.89 (0.840.95, P <0.001) for moderate, and 0.93 (0.870.99, P =0.026) for heavier alcohol consumers. Such an inverse association of alcohol intake and the development of CKD was observed in men with all drinking groups, whereas only found in women with mild drinking group. Conclusions: Our study showed that alcohol consumption was inversely associated with the risk of developing CKD.
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