대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Risk factors and transitional probability of clinical events in korean CKD patients using the multi-state model: from the KNOW-CKD study
저자	Ji Hye Kim
출판정보	2023; 2023(1):
키워드
초록	Objectives: Compared to western countries, Korean CKD patients show distinctive differences in clinical outcomes including lower cardiovascular disease (CVD) and higher end-stage kidney disease (ESKD) events. This study analyzed the risk factors, transition probability and cumulative hazards associated with clinical events using the multi-state model. Methods: This study included 1423 patients at CKD stages 1-4 from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease. Multivariate multi-state model analysis was performed to investigate the risk factors, 10-year transition rate and cumulative hazard estimates for five clinical event status including ESKD, CVD, death, death after ESKD and death after CVD events. Results: Among 1423 patients (age 54 [44-63] years), the overall prevalence of clinical events were the following: ESKD (22.6%), CVD (7.5%), death (3.3%), death after ESKD (3.6%) and death after CVD (1.2%). Different risk factors were associated with different clinical outcomes and in particular the risk factors associated with higher ESKD event were underlying CVD, diabetes, polycystic kidney disease, fibroblast growth factor-23 while hypertension, increased age and estimated glomerular filtration rates were associated with lower risks. The 10-year progression probability for each event status include the following: 0.23 for ESKD, 0.08 for CVD, 0.04 for death, 0.09 for death after ESKD and 0.01 for death after CVD. The 10-year cumulative hazard estimates for each event status were the following: ESKD [0.43, 95% CI (0.37-0.49)], CVD [0.12, (0.10-0.15)], death [0.05, (0.03-0.06)], death after ESKD [0.52, (0.20-0.84)] and death after CVD [0.27, (0.15-0.40)]. Conclusions: Different risk factors were associated with varying clinical outcomes in Korean CKD patients. The 10-year progression probability was the highest in ESKD followed by death after ESKD events. Also, the 10-year cumulative hazard estimate was the highest for death after ESKD followed by ESKD events. These findings correlate with the distinctive clinical outcome features of Korean CKD patients.
원문(PDF)	PDF 원문보기

목록

위로가기