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논문분류	춘계학술대회 초록집
제목	Safety and efficacy assessment of 3d printed autologous omentum patch to delay renal fibrosis
저자	BOYOUNG CHOI
출판정보	2023; 2023(1):
키워드
초록	Objectives: Renal fibrosis and tubulointerstitial damage accompany the course of chronic kidney disease with slow progression towards end-stage renal disease (ESRD). Although many researchers have widely studied promising new technologies to treat kidney disease, the only clinically viable options for ESRD patients are dialysis and kidney transplantation. In this study, we studied new approach to delay the progression of ESRD using autologous omentum tissue. Both the efficacy and safety of the omentum patch were evaluated using animal models. Methods: We micronized the autologous omentum tissue and used it as a bioink. The omentum patch printed with 3D bioprinter was transplanted under renal capsule layer. First, we investigated the anti-fibrosis effect of the patch using unilateral ureteral obstruction (UUO) rat models. RNA Seq and histological analysis were performed on renal tissue of each group after 2 weeks of transplantation.Second, we confirmed the safety of transplanting the omentum patch in 7 micropigs for 12 weeks. Results: The rodent model: Decreased tubular damage was observed in the omentum patch group compared control group. In particular, expression of fibrosis-related gene was significantly reduced in differentially expression genes by bulk RNA sequencing. The porcine model: After transplanting patches, the results of kidney functional capacity and electrolytes testshowed no significant difference from normal range. Also, the inflammatory response after patch transplantation was not clinically visible in H&E staining. Ultrasound doppler examination was used to calculate the resistive index, and renal vascular resistance of the patch transplant group was in normal ranges. Conclusions: Therefore, the experimental results from two different models suggest that the omentum patch can be transplanted into kidney in a stable condition, and help to reduce ESRD progression by inhibiting renal fibrosis. The omentum patch has the potential to be used as a treatment for the kidney repair and regeneration.
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