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논문분류	춘계학술대회 초록집
제목	SERUM CYSTATIN C AS A POTENTIAL PREDICTOR OF RENAL DAMAGE IN PRE-ECLAMPSIA
저자	Thanh-Tam Tran-Thai
출판정보	2023; 2023(1):
키워드
초록	Objectives: Pre-eclampsia is a pregnancy-related disorder characterized by hypertension, proteinuria, and edema. Serum cystatin C is a novel marker for the early detection of renal damage in pre-eclampsia. Therefore, the study aimed to determine the average value of renal function indexes and some factors related to serum cystatin C levels in pre-eclamptic pregnant women. Methods: A case-control study investigated two pregnant women groups: 50 healthy pregnant women (group A) and 50 pregnant women with pre-eclampsia (group B) at Can Tho Obstetrics and Gynecology Hospital, Vietnam, from July 2021 to July 2022.We collected blood samplesand urine samples to analyze the serum cystatin C concentration and the indices of renal function. Results: Theaverage maternal age of healthy pregnant women and pre-eclampsia group was respectively 31.3±6.4 and 33.5±6.4 years old (p>0.05), and the gestational age of the healthy group and pre-eclampsia group was 37.0and37.1 weeks (p>0.05). Indices of kidney function in 2 groups of healthy pregnant women and pre-eclampsia pregnant women were, respectively: serum creatinine (Scr) 50.7±8.9 and 54.5±11.4mol/L (p>0.05), serum cystatin C (ScysC) 0.9±0.21and1.4±0.18mg/L (p<0.01), 24-hour proteinuria 221.3±35.3 and 799.5 (306-3720)mg/24hours (p<0.01), urine creatinine 1253.6±424.9 and 1390.8±480.7mg/24 hours (p>0.05), 24-hour creatinine 153±48and 162.5±62mL/min (p>0.05). The correlation between Scr, ScysC, and 24-hour creatinine clearance in group A was r1=-0.52 (p<0.001), r2=0.06 (p=0.695); in group B, was r3=-0.45 (p=0.001), r4=0.26 (p=0.064). The correlation between Scr, ScysC, and 24h proteinuria in group A was r5=0.05 (p=0.851), r6=0.26 (p=0.064); in group B, was r7=0.24 (p=0.094), r8=0.36 (p=0.01), respectively. Conclusions: Serum cystatin C seems to be not as accurate as serum creatinine in evaluating the glomerular filtration ratein pregnant women; however, this is a promising biomarker for the early detection of renal injury in preeclampsia.
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