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논문분류	춘계학술대회 초록집
제목	Renal function improvement effects of the extract kecombrang (etlingera elatior) fruit in mice model of sepsis
저자	Evi Nurhayatun
출판정보	2023; 2023(1):
키워드
초록	Objectives: Sepsis is a condition with high morbidity and mortality, accompanied with high burden expenses. Acute kidney injury is one of the complications of organ damage due to sepsis. This study investigated the effects of an extract ofKecombrang(E. elatior) fruit onrenalfunctionimprovement in sepsis model mice. Methods: Forty Mus musculus mice were divided into five groups (n = 8), and the intervention group received 0.03 mg/kg BW lipopolysaccharide (LPS) intraperitoneal. There was a normal group without LPS induction (E-1), one with LPS injection only (E-2), and those that received ethanol extracts ofKecombrangfruit containing 2.1 mg/20 g (E-3), 4.2 mg/20 g (E-4), and 8.4 mg/20 g (E-5). ELISA was used to gauge NGAL levels. The ANOVA was conducted to examine the differences between the groups. Results: After administration of the extract at a varied dose, the lowest NGAL levels were in the E-5 group (8.4mg/20g; p=0.001).Ethanol extract ofKecombrang(E. elatior)fruithasantiinflamatoryeffects. In this study, a dosage of 8.4 mg/20g of extract may significantly lower the levels of NGAL Conclusions: The ethanol extract of E. elatior might be considered a complementary treatment to decrease inflammation and kidney injury in sepsis.
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