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논문분류	춘계학술대회 초록집
제목	Association of a low protein diet with depressive symptoms and poor health-related quality of life in CKD
저자	Dong-Young Lee
출판정보	2023; 2023(1):
키워드
초록	Objectives: A low protein diet (LPD) for chronic kidney disease (CKD) is a core dietary therapy as it has been demonstrated to slow CKD progression. Herein, we sought to evaluate the effectof LPD on depressive symptoms and health-related quality of life (HRQOL) in persons withCKD. Methods: We included 571 pre-dialysis CKD patients in our analyses. The subjects were dichotomized into a LPD group if the subjects’ dietary protein intake was less than or equal to0.8 g/Kg/day, otherwise they were in the conventional protein diet (CPD) group. Multivariateodds ratio (OR) and 95% confidence interval (95% CI) for depressive symptoms and poorHRQOL were evaluated to clarify the association between a LPD and depressive symptoms orpoor HRQOL. The subgroups were classified by the diabetic kidney disease (DKD, DKDversus non-DKD) and CKD stages (non-advanced CKD (CKD stage 1, 2, and 3) versusadvanced CKD (CKD stage 4, and 5)) and we also assessed the relationship of a LPD withdepressive symptoms or poor HRQOL of each group. Results: The LPD group showed an increased Korean-Beck Depression Inventory-II (K-BDIII) score indicating depressive symptoms and a decreased EQ-5D-5L index compared to theCPD group. The LPD group had a 1.8 OR (95% CI, 1.15-2.81) for depressive symptoms and1.99 OR (95% CI, 1.41-3.12) for lower HRQOL scores. The LPD group was associated withan increased OR of 1.99 [1.09-3.65] in the DKD subgroup and 2.05 [1.12-3.75] in the advancedCKD subgroup for depressive symptoms. Conclusions: LPD was associated with an increased probability of depressive symptoms and poor HRQOL. This suggests that close monitoring of depression and QOL during LPD in CKD.
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