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논문분류	춘계학술대회 초록집
제목	Loss of Cutibacterium is responsible for CKD-associated pruritus in patients undergoing dialysis
저자	Jeong Geon Lee
출판정보	2023; 2023(1):
키워드
초록	Objectives: The pathogenesis of CKD-associated pruritus is poorly understood, although it is a serious problem worldwide. The microbiome that makes up the skin might be responsible for pruritus. Therefore, we tried to confirm the relationship between CKD-associated pruritus and skin microbiome in this study. Methods: A total of 91 patients in Soonchunhyang University Cheonan Hospital (15 control group, 40 End-Stage Kidney Disease (ESKD) patients undergoing hemodialysis, 36 ESKD patients undergoing peritoneal dialysis) were enrolled, and swabbed in three sites; back (sebaceous area), antecubital fossa (moist area), and shin (dry area). Also, enrolled patients have done a questionnaire, which is a combination of the three methods (WI-NRS, 5-D itch scale, UP-Dial). 16S gene-based metagenomics method was applied to skin microbiome analysis. Results: The data showed a significant microbial change in the back between the control group and the ESKD group. Here, the average composition ratio of Cutibacterium genus in the back was significantly lower in the ESKD group than the control group (p < 0.05). As a result of further analysis of the two groups of low pruritus and high pruritus among ESKD patients, here too, Cutibacteriumwas significantly lower in the high pruritus group compared to the low pruritus group (p < 0.05). The data showed that the skin microbiome had affected the degree of pruritus since other clinical parameters, such as age, eGFR, hemoglobin, Ca×P, and intact parathyroid hormone didn't show significant differences. Conclusions: In ESKD patients, back was related to the changed skin microbiome characteristics, and it was confirmed that this severity correlated with the reduction of Cutibacterium. This research is the first research worldwide to figure out the relationship between CKD-associated pruritus in ESKD patients and the skin microbiome.
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