대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	The difference between cystatin C- and creatinine-based estimated glomerular filtration rate and incident atrial fibrillation in the UK biobank
저자	Ga Young Heo
출판정보	2023; 2023(1):
키워드
초록	Objectives: Recent studies showed that a lower difference between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFR) is associated with a higher risk of adverse outcomes, such as cardiovascular disease, hospitalization, and mortality. However, the relation between these differences and the development of atrial fibrillation (AF) is not well known. Methods: Participants from UK Biobank without prior or concurrent AF and with serum creatinine and cystatin C measurements at baseline were included in this study. The primary exposure was the difference between two eGFR estimates (eGFRdiff), subtracting creatinine-based eGFR from cystatin C-based eGFR, and the primary outcome was incident AF. The subdistribution hazard model was used to assess the association of eGFRdiff with incident AF and all-cause death was treated as competing risk. Results: Of 340,143 participants, 179,055 (52.6%) were female, and the mean (SD) age was 56.2 (81) years. During a median follow-up of 11.7 years, incident AF occurred in 17,843 (5.2%) participants. Participants with higher eGFRdiff were younger, and had better metabolic profiles and functional status. In the multivariate-adjusted model, compared to participants with midrange eGFRdiff (-15 to 15 mL/min/1.73 m2), participants with the negative eGFRdiff (<-15 mL/min/1.73 m2) had a higher risk of incident AF (subdistribution hazard ratio [sHR], 1.26; 95% confidence interval [CI], 1.21-1.31), while participants with the positive eGFRdiff (≥15 mL/min/1.73 m2) category had a lower risk of AF (sHR, 0.82; 95% CI, 0.77-0.88). In the adjusted model treating eGFRdiff as a continuous variable, a 10 mL/min/1.73 m2 increase in eGFRdiff was associated with a 0.90-fold decreased risk of AF development (sHR, 0.90; 95% CI, 0.88-0.91). Conclusions: This study showed that a larger eGFRdiff is associated with a lower risk of AF.
원문(PDF)	PDF 원문보기

목록

위로가기