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논문분류	춘계학술대회 초록집
제목	Association factors for changing in urinary phthalate metabolites in patients with chronic kidney disease during COVID-19 pandemic: sketch trial
저자	Yaerim Kim
출판정보	2023; 2023(1):
키워드
초록	Objectives: Urinary phthalate metabolites could only reflect recent episodic exposure because of the rapid metabolizing process, there are limitations to evaluating the disease associated with only one measurement value. Herein, we aimed to evaluate the association between urinary phthalate metabolites and kidney function based on the repeatedly measured value. Methods: Among chronic kidney disease (CKD) patients registered in a SKETCH (Study on Kidney disease and EnvironmenTal Chemicals, Clinical Trial No. NCT04679168) cohort, who were followed up every 3 months over 1 year were included in the study. Repeatedly collected urine in each visit was used to analyze phthalate metabolites. We used Spearman’s rank correlation test and linear mixed effects models to evaluate association. Results: A total of 249 patients were finally included in the study. There were 40, 137, and 72 patients with estimated glomerular filtration rate (eGFR) ≥60, 30-60, and <30, respectively. Age was negatively correlated with phthalate (r=-0.399, P=0.017) and alternative phthalate (r=-0.358, P=0.023) in patients with eGFR ≥60. Also, there was significant positive correlation between serum hemoglobin and alternative phthalate in patients with eGFR ≥60 (r=0.430, P=0.006) and eGFR 30-60 (r=0.237, P=0.005). Negative correlation between serum glucose and phthalate was observed in patients with eGFR 30-60 (r=-0.168, P=0.050). In addition, negative correlation between total cholesterol and phthalate was observed in patients with eGFR <30 (r=-0.234, P=0.050). We found the associations between changing in eGFR and urinary phthalate metabolites such as MEHP (β 0.94, 95% CI 0.52-1.36), cx-MEPP (β 0.66, 95% CI 0.12-1.21), cx-MEPTP (β 0.86, 95% CI 0.47-1.26), OH-MEHTP (β 0.57, 95% CI 0.22-0.92), oxo-MEHTP (β 0.56, 95% CI 0.30-0.83), and cx-MEPA (β0.85, 95% CI 0.38-1.32). Conclusions: Urinary phthalate metabolites have a significant association with kidney function deterioration. The associative effect differed in each metabolite and according to the baseline kidney function.
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