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논문분류	춘계학술대회 초록집
제목	Cinnamic acid one of the major phenolic acids derived from the bark of trees from the genus cinnamomum , reduces renal tubulointerstitial fibrosis
저자	Gireesh Dayma
출판정보	2023; 2023(1):
키워드
초록	Objectives: The renal fibrotic process is characterized by a chronic inflammatory state and oxidative stress.Cinnamic acid is commonly usedas flavor compound in foods and drinks, and for its aroma in perfumes and cosmetics. Cinnamic acid is naturally found in the spice cinnamon, which is derived from the bark of trees from the genus Cinnamomum. Methods: We investigated whether oral administration of polyphenol-rich extract fromCinnamomum verumcould exert in vivo a curative anti-renal fibrosis effect. To this aim, three days after unilateral ureteral obstruction (UUO), rabbits were daily orally treated either with a non-toxic dose of polyphenol-rich extract fromCinnamomum verumor Cinnamic acid with for 5 days. Results: The polyphenol-rich extract fromCinnamomum verum, as well as CA, the predominant phenolic acid of this medicinal plant, exerted a nephroprotective effect.through the reduction in the three phases of the fibrotic process: (i) macrophage infiltration, (ii) myofibroblast appearance and (iii) extracellular matrix accumulation. These effects were associated with the mRNA down-regulation of IFN- gamma, IL-2,TGF-β,TNF-α,Mcp1andNFkB, as well as the upregulation ofNrf2. Importantly, we observed an increased antioxidant enzyme activity for GPX and Cu/ZnSOD. Last but not least, desorption electrospray ionization-high resolution/mass spectrometry (DESI-HR/MS) imaging allowed us to visualize, for the first time, CA in the kidney tissue. Conclusions: The present study demonstrates that polyphenol-rich extract fromCinnamomum verumsignificantly improves, in a curative way, renal tubulointerstitial fibrosis progression in the UUO rabbit model.
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