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논문분류	춘계학술대회 초록집
제목	The effect of exercise intervention on sarcopenia-related variables in adult patients undergoing peritoneal dialysis: a systematic review of randomized controlled trials
저자	Bianda Aulia
출판정보	2023; 2023(1):
키워드
초록	Objectives: Exercise may improve sarcopenia outcomes in end-stage renal disease, but there is no clear conclusion in peritoneal dialysis (PD). This review aimed to evaluate the effect of exercise training on outcomes related to sarcopenia including muscle strength, muscle quantity, and physical performance in patients receiving PD. Methods: A systematic search for randomized controlled trials (RCTs) was performed using PubMed (MEDLINE),Cochrane Central Register of Controlled Trials (CENTRAL), and Scopus databases from the date of establishment to 31 December 2022 using combinations of the following keywords: “chronic kidney disease”, “peritoneal dialysis”, “exercise”, and “physical activity”. RCTs were included if they involved any type of exercise training in PD. Results: Out of 369 screened, 4 studies were included in the review, consisting of 183 participants. The median duration of intervention was 12 weeks, and most studies used a combination of aerobic and resistance exercise. The mean difference of handgrip strength was not statistically significant between control and intervention groups in all studies (p>0.05). Synthetized data showed increased repetitions of 30s sit-to-stand test (MD=1.90, 95% CI 0.18-3.62,p= 0.03, I2= 51%). There is only one trial reporting muscle mass outcome (skeletal muscle index (kg/m2)) and no effect was observed after the intervention. Exercise significantly improved timed up-and-go test after 12 weeks training (SMD = -0.75 s, 95% CI 1.360.14, I2= 41%). One trial also showed an increase in 6-minute walking test (m) in the exercise group but not in controls at 3 and 6 months after the intervention. Conclusions: Aerobic and combined exercise may be a potential strategy to improve muscle strength and physical performance in people undergoing PD. However, there is still limited evidence of exercise intervention in peritoneal dialysis. Larger and high-quality studies are needed to fully elucidate the impact of exercise on sarcopenia-related outcomes in this population.
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