대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Risk of all-cause mortality with aortic arch calcification in dialysis patients
저자	Mohammad Salman Hussain
출판정보	2023; 2023(1):
키워드
초록	Objectives: Epidemiological studies linked aortic arch calcification (AAC) with all-cause mortality risk in dialysis patients. Available evidence presented variable findings and raised conflict. Therefore, this study aimed to compute the pooled risk of all-cause mortality with AAC in dialysis patients. Methods: An extensive literature search was performed in PubMed, Embase, and Cochrane databases for studies related to AAC and all-cause mortality in dialysis patients. The primary outcome was to compute the pooled risk of all-cause mortality due to AAC. The secondary outcome was to compute the risk based on dialysis modalities, cardiovascular, AAC grade, geography, and others. The certainty of findings was assessed using the GRADE criteria. Meta-analysis was performed using Review Manager v5.3.5. Results: This meta-analysis was based on nine studies with 3446 dialysis patients. The mean age of the patients was 58.48 ± 11.88 years. All-cause mortality risk was significantly higher in dialysis patients with AAC compared to dialysis patients without AAC with a pooled risk ratio (RR) of 1.53 (95% CI: 1.20 1.97), p = 0.0007 (Fig.1). Subgroup analysis found significantly higher risk in peritoneal dialysis (PD) patients [RR 2.50 (95% CI: 1.74 3.60), p <0.00001] as compared to hemodialysis (HD) patients [RR 1.28 (95% CI: 1.01 1.61), p = 0.04]. Likewise, grade 2+3 AAC patients [RR 1.77 (95% CI: 1.34 2.33), p <0.0001] had significantly higher all-cause mortality risk as compared to grade 1 AAC patients [RR 1.35 (95% CI: 1.03 1.77), p = 0.03]. Conclusions: AAC in dialysis patients was associated with a higher risk of all-cause mortality in HD and PD patients. Future well-designed studies with larger sample sizes are needed to make the evidence more robust.
원문(PDF)	PDF 원문보기

목록

위로가기