대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Nephroprotective potential of Gallic acid metformin against Streptozotocin induced diabetic nephropathy in Wistar rats via inhibition of DPP-4 and TGF-β
저자	Vikas Kumar
출판정보	2023; 2023(1):
키워드
초록	Objectives: The current experimental study was make attempt to explore the renal protective effect of gallic acid- metformin (GA-Met) against the STZ induced diabetic rats via inhibition of DPP-4 and TGF-β. Methods: GA-Met was scrutinizing against the DPP-4 inhibitor. GA-Met were also examined via Insilco study with the structure of DPP-4 to identify the critical interactions for its bioactivity. STZ was used for induction the type 2 diabetes and blood glucose level, biochemical, antioxidant, cytokines and inflammatory mediators were estimated. Results: DPP-4 assay, GA-Met was found as potential drug with IC50 value = 4.34 M. GA-Met Insilco interacted with various residue of DPP-4 inhibitor. GA-Met significantly reduced the blood glucose level (67%) and increased the plasma insulin level (45.5%). GA-Met improve the interstitial fibrosis, tubulointestitial injury and inflammatory cell infiltration in animal tissue. GA-Met exhibited the significantly decreasethe level of TNF-α (45%), Il-1β (54.3%). IL-6 (56.1%), caspase-1 (43%), caspase-3 (40.4%), COX-2 (65%). PGE2 (60.3%) and NF-kB (52.3%). Oxidative stress marker and the expression of transforminggrowth factor-β (TGF-β) in the renal tissue of diabetic rats were significantly (P<0.001) altered by GA-Met treated group rats. Conclusions: The current investigation suggests that GA-Met exert the renal protective effect against the STZ induced DN rats via inhibition of DPP4 and TGF-β.
원문(PDF)	PDF 원문보기

목록

위로가기