대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Solid lipid nano-particles of quercetin to abrogate renal dysfunction in experimentally induced type ii diabetic rats: an anti-inflammatory therapy
저자	Deeksha Chauhan
출판정보	2023; 2023(1):
키워드
초록	Objectives: In the present study, we try to explore the molecular mechanism of Solid lipid nanoparticles (SLN) of qurectin in experimental induced DN in Streptozotocin (STZ) treated rats. Methods: : For SLN preparation, double emulsion displacement method was used. STZ (55 mg/kg) was used for the induction of DM and rats were divided into different group and received the treatment of QE and QE-SLN for 4 weeks. The body weight, plasma insulin, biochemical, antioxidant parameters were estimated, respectively. pro-inflammatory cytokines viz., TNF-α, IL-1β and IL-6 inflammatory mediator Nuclear transcription factor-kappa B (Nf-kB) and PGE2 were scrutinized, respectively. NF-κB, IL-6 and TNF-α expression of renal were also estimated, respectively. The renal tissue was further used for the histopathological observation. Results: QE-SLNs were evaluated for potential entrapment, particle size, drug release stability and gastric stability. QE-SLNs treatment demonstrated the down-regulation of blood glucose level and up-regulation of plasma insulin (25%), body weight (20%). Additionally, QE-SLNs treatment modulated the biochemical and antioxidant parameters. QE-SLNs treatment exhibited decreased level of IL-1β (32%), TNF-α (41%), IL-6 (29%), PGE2 (34%) and Nf-kB (42%). Moreover, QE-SLNs showed the alteration in the expression of TNF-α and Nf-kB. Histopathology suggests the less necrosis, infiltrated blood vessels and less swelling in vessels. Conclusions: We can conclude that QE-SLNs nano-formulation can prevent the Diabetic nephropathy via alteration of Nf-kB pathway.
원문(PDF)	PDF 원문보기

목록

위로가기