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논문분류	춘계학술대회 초록집
제목	Evaluation of thyroid function in chronic kidney disease in children
저자	Jatinkumar Dhanani
출판정보	2023; 2023(1):
키워드
초록	Objectives: To evaluate the prevalence of hypothyroidism in children with CKD and the relationship between hypothyroidism and degree of proteinuria. Methods: Observational cross-sectional study, conducted in a tertiary care teaching hospital, west India from March 2010 to Feb 2022. The data of the patients from 1 years to 18 years of age with diagnosed cases of CKD (stages 25), who visited multi-disciplinary CKD clinic were reviewed. The data like anthropometric measurements, baseline laboratory investigations including spot urine protein creatinine ratio(UP: UC), thyroid function test (electrochemiluminescence method), and antiTPO(thyroid peroxidase) antibody level were recorded. SPSS version 23.0 was used for analysis. Results: Fifty cases were enrolled. The mean age of presentation was 102 ± 53 months, and 76% were boys. Overall, 13 cases (26%) had hypothyroidism. The prevalence of hypothyroid cases increased as CKD stages advanced (23% of hypothyroid cases [3/13] in CKD stage 23 vs. 73% of hypothyroid cases [10/13] in CKD stage 45). No hypothyroid case was found when spot UP: UC was <0.2. Higher UP: UC was associated with an increased prevalence of hypothyroidism. CKD cases in sub-nephrotic proteinuria group, 20% had hypothyroidism, while in nephrotic-range proteinuria group thisproportion was 39.1%. The Pearson correlation between TSH and spotUP: UC in overt hypothyroid cases was moderate positive (r = 0.56). Conclusions: 26% of children with CKD were observed with hypothyroidism (subclinical or overt) especially in the presence of higher degree of proteinuria. Large multicentric studies are necessary to establish the correlation.
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