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논문분류	춘계학술대회 초록집
제목	Effect of probiotic supplement on metabolic parameters in patients with diabetic nephropathy : a systematic review
저자	Shinta Retno Wulandari
출판정보	2023; 2023(1):
키워드
초록	Objectives: Diabetic nephropathy (DN), a complication of diabetes, is one of the main causes of end-stage renal disease. Probiotic supplements were reported as a strategy for modulating gut micro-flora and have favourable effects on renal function. This study aimed to research the effect of probiotic supplement on metabolic parameters in patients with DN. Methods: We conducted a systematic review of all studies published between 2019 2023, on outcome of probiotic supplementation on patients with DN. Through a comprehensive search on PubMed and Cochrane Library. Terms used in this research were included MeSH headings for probiotic and metabolic and DN. We identified two eligible studies. Risk of bias analysis was performed using the Cochrane Risk of Bias Tool. Results: 30 patients with DN received 25g/day probiotic honey containing probioticBacillus coagulansT11 (108CFU/g) (treatment) and 30 patients received 25g/day control honey (n=30 each group) for 12weeks. After 12weeks of intervention, patients who received probiotic honey compared with the control honey had significantly decreased serum insulin levels (1.2±1.8 vs. 0.1±1.3μIU/mL,P=0.004). Another study stated that 42 patients received 3.2 × 109 CFU per day of probiotics containing (Bifidobacterium bifidum 1.2 × 109 CFU, Lactobacillus acidophilus 4.2 × 109 CFU, Streptococcus thermophilus 4.3 × 109 CFU) for 12 weeks and 34 patients received empty capsules for 12 weeks. After 12 weeks there was a significant reduction in fasting blood glucose (10.68 ± 3.24 mmol/L before vs. 7.81 ± 2.77 mmol/L after, p < 0.05), HbA1c (8.19 ± 1.60% before vs. 7.32 ± 1.20% after, p < 0.05) and mAlb/Cr (101.60 ± 22.17 mg/g before vs. 67.53 ± 20.11 mg/g after, p < 0.05), Conclusions: This study showed that probiotic administration could ameliorate metabolic parameter of patients with diabetic nephropathy.
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