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논문분류	춘계학술대회 초록집
제목	Dialysis Membranone in HD Beyond the Basic
저자	Soonkil Kwon
출판정보	2024; 2024(1):
키워드
초록	Dialysis membranes by their efficiency The development of dialysis membranes has continued to achieve maximum uremic toxin removal. The hollow-fiber dialysis membrane, developed in the 1960s, is an innovative structure that achieves effective blood filtration by maximizing the contact area. In earlier days, membranes were manufactured to remove urea nitrogen, but after further identification of the importance of medium-molecular substances, membrane permeability was improved to remove larger molecules. Also, the importance of protein-bound uremic toxins became known, leading to the development of ‘protein-permeable’ membranes with larger mean pore size dialysis membranes. Dialysis membranes by their substances and function A Cuprophan was initially used because it had a good effect in removing urea nitrogen, but it was unable to remove large molecular substances and had low biocompatibility. Synthetic membranes are in the form of polymer fibers and are more widely used as it is superior to cellulose in removing heavy molecular substances, have an increased survival rate compared to cellulose, and have a better adsorption effect on pro-inflammatory proteins. Efforts were also made to reduce inflammatory reactions and oxidative stress in hemodialysis patients. After applying cellulose-based vitamin E-coated membrane (VEM), lipid peroxidation, pro-inflammatory cytokines, CRP, and IL-6 were reduced. Neutrophil elastase (NE) inhibitor‑modified membrane inhibits an NE, which causes inflammation and erythropoietin resistance in dialysis and showed positive results. In addition, the effectiveness of lipoic acid-coated membranes was also shown. Recently, attempts to reduce inflammation via bioactive compounds-coated membranes. There has been research on improving survival in acute kidney disease by coating growing kidney epithelial cells or porcine primary renal cells on semipermeable hollow fiber membranes. Efforts are ongoing to classify them as living membranes and develop them into bioartificial kidney devices.
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