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논문분류	춘계학술대회 초록집
제목	Stem Cells and Chronic Kidney Disease
저자	Cai-Mei Zheng
출판정보	2024; 2024(1):
키워드
초록	Chronic kidney disease (CKD) represents a significant challenge to global health, progressively impairing renal function and straining healthcare systems. Stem cell therapy, especially using allogeneic adipose tissue-derived stem cells (ADSCs), has emerged as a promising regenerative approach. Our phase I clinical trial assessed the safety and preliminary effectiveness of ELIXCYTE® in individuals with moderate to severe CKD. In this trial, 12 patients were categorized into three dosing groups and administered ELIXCYTE® intravenously, with subsequent monitoring over 48 weeks to evaluate safety and kidney function. The trial outcomes indicated a positive safety profile and potential improvement in kidney function among certain patients, highlighting the prospective role of ADSCs in slowing CKD progression. These encouraging results advocate for additional studies to refine treatment methodologies, ascertain long-term impacts, and determine the most suitable candidates for stem cell therapy. The initial success of this phase I study facilitates further investigation into ADSCs for CKD management, albeit acknowledging the obstacles in transitioning from laboratory research to clinical application. The field of stem cell biology and regenerative medicine is rapidly evolving, offering fresh perspectives on therapeutic mechanisms, such as anti-apoptotic, anti-fibrotic, and anti-inflammatory properties of stem cells. In summary, our ELIXCYTE® study introduces stem cell therapy as an innovative treatment paradigm for CKD, with the potential to revolutionize patient care and improve outcomes. This pioneering research emphasizes the importance of continuous collaboration and scientific exploration to fully exploit the therapeutic capacity of stem cells in addressing kidney diseases.
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