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논문분류	춘계학술대회 초록집
제목	Clinical Outcomes of Hemoperfusion using HA330 Filter among patients with Severe and Critical COVID-19 at the University of Santo Tomas Hospital: A One Year Retrospective Study
저자	Juan Miguel Dizon
출판정보	2024; 2024(1):
키워드
초록	Objectives: The research aims to determine the clinical outcomes of patients with severe and critical COVID-19 who underwent hemoperfusion at the University and Santo Tomas Hospital. Methods: This retrospective study included 135 severe and critical COVID-19 patients who underwent hemoperfusion using an HA330 cartridge. APACHE II score, hemoglobin, blood counts, serum creatinine, ferritin, hs-CRP, IL-6, LDH, procalcitonin, D-dimer, PaO2/FiO2 ratio were compared pre and post-hemoperfusion among survivors and non-survivors. The effects of the timing of hemoperfusion on clinical parameters and outcomes were described. Results: APACHE II score was lower post-hemoperfusion compared to baseline levels among survivors. Post-hemoperfusion, hemoglobin, and platelet counts were lower among non-survivors. WBCs increased among all patients. Neutrophils increased while lymphocytes decreased among non-survivors. There is no significant change in creatinine compared to the baseline. Post-HP ferritin, LDH, and D-dimer were elevated among non-survivors. HsCRP and procalcitonin were lower while ferritin and D-dimer increased among survivors post-HP. IL-6 levels showed no significant difference post-HP but we reported higher levels among non-survivors versus survivors. PaO2/FiO2 ratio was higher among survivors versus non-survivors. The effect of the timing of hemoperfusion was divided within 14 days versus beyond 14 days of illness. APACHE II scores were lower for those who underwent hemoperfusion within 14 days. There was no significant difference compared to baseline levels of blood counts, inflammatory markers, and PaO2/FiO2 ratio among those who underwent hemoperfusion beyond 14 days. Hemoglobin, hs-CRP, IL-6, and procalcitonin were lower while neutrophils, ferritin, d-dimer, and PF ratio increased among those who had hemoperfusion within 14 days. Conclusions: Hemoperfusion results in lower APACHE II scores, hemoglobin, HsCRP, and procalcitonin levels. There was no significant difference from baseline clinical parameters among those who underwent hemoperfusion beyond 14 days of illness. Those who underwent hemoperfusion within 14 days of illness required less invasive mechanical O2 support
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