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논문분류	춘계학술대회 초록집
제목	Analysis Of Risk Factors And Outcome In Peritoneal Dialysis Patients With Early-Onset Peritonitis: A Single Center Retrospective Analysis
저자	Pamela Elaine Mangabat
출판정보	2024; 2024(1):
키워드
초록	Objectives: Peritonitis is a major cause of withdrawal of patients from Peritoneal Dialysis modality. Therefore, preventing the development of peritonitis through identification of the risk factors associated with Early-Onset Peritonitis is crucial. This study investigated the risk factors associated with early-onset peritonitis and their influence on patients’ technique survival and mortality in the largest renal center in the Philippines. Methods: This is a retrospective cohort study of 552 newly initiated peritoneal dialysis patients in a tertiary renal center from January 1, 2019 to December 31, 2021. Patients were divided into Peritonitis-free (n=251), Early-onset peritonitis (<6 months, n=136) and Late-onset peritonitis (> 6 months, n=165) groups. Logistic regression was used to analyze risk factors associated with Early-onset peritonitis. Cox proportional hazard model was used to determine the effect of early-onset peritonitis on clinical outcomes. Results: Of 552 peritoneal dialysis patients, 24.6% developed Early-onset peritonitis. Mean serum albumin is significantly lower in patients with Early-onset peritonitis (3.16 ± 0.51 g/dL) among the three groups. Higher BMI [HR of 1.07(95% CI 1.02 to 1.14)] and a shorter time-to-first-peritonitis [HR of 0.97 (95% CI 0.96 to 0.98)] cause significant risk to technique failure. Shorter time-to-first peritonitis (HR=.95, 95% CI 0.91 to 0.99) and higher Charlson Comorbidity Index score (HR=1.31, 95% CI 1.03 to 1.66) are significantly associated with mortality. Early-onset peritonitis had a lower cure rate (44.9% vs 68.5%), higher recurrence and relapse rate (30.1% vs 9.1%), higher rate of transferring to hemodialysis (25% vs 22.4%) and higher mortality (58.5% vs 34%) compared with Late-onset peritonitis. Conclusions: Early-onset peritonitis was strongly associated with poor clinical outcomes. Early identification of the risk factors associated with peritonitis is crucial to reduce complications and reduce withdrawal of patients from peritoneal dialysis modality.
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