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논문분류	춘계학술대회 초록집
제목	Polygenic scores for hypertension and low-density lipoprotein cholesterol and risk of incident chronic kidney disease
저자	Dong Hoon Kang
출판정보	2024; 2024(1):
키워드
초록	Objectives: A higher polygenic risk score (PRS) for kidney function is associated with the development of chronic kidney disease (CKD). However, the association of PRSs for risk factors with risk of CKD is unknown. This study examined whether PRSs for hypertension and low-density lipoprotein cholesterol (LDL-C) can collectively predict the future development of CKD. Methods: We included 344,096 participants enrolled in the UK Biobank between 2006 and 2010 who were followed up until 2022. PRS hypertension and PRS LDL-C were used as the primary exposures. The primary outcome was the onset of incident CKD, which was defined based on ICD-10 or OPCS-4 codes. We examined the individual and combined association of the PRS hypertension and PRS LDL-C with the risk of incident CKD using cause-specific competing risk models. Results: The mean age of the participants was 56.1 years and 46.8% were men. During a follow-up of 13.6 years (interquartile range 12.8−14.2), 13,379 individuals experienced CKD. A 1-SD increase in PRS hypertension was associated with a 5% higher risk of incident CKD (hazard ratio [HR], 1.05; 95% confidence interval [CI] 1.03−1.07). However, PRS LDL-C was not associated with incident CKD. When both participants were divided into two groups based on the median values of PRSs for hypertension and LDL-C, the HRs (95% CIs) for individuals with both above the median, those with higher PRS hypertension and lower PRS LDL-C, and those with lower PRS hypertension and higher PRS LDL-C were 1.09 (1.03, 1.14), 1.06 (1.01, 1.12), and 1.03 (0.98, 1.08), respectively, compared with those with both below the median. Conclusions: This study showed a significant association between PRS hypertension and a higher risk of CKD, while PRS LDL-C showed no such association. These two genetic predisposing factors appear to synergistically contribute to a higher risk of CKD when both PRS values are elevated.
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