대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Interaction of Phosphate and Uremic Substances on Vascular Calcification
저자	Masahide Mizobuchi
출판정보	2024; 2024(1):
키워드
초록	Objectives: We investigated the involvement of phosphate (P) and indoxyl sulfate (IS), a uremic substance in vascular calcification in renal failure. Methods: After culturing vascular smooth muscle cells (VSMCs) in a regular media (control) or P- and/or IS-loaded media for 10 days, VSMC calcification and expression of the chronic inflammatory state associated with aging (inflammaging) marker genes were examined by real-time PCR. We also investigated calcification and inflammaging marker gene expression in the aortas of adenine-induced renal injury mice treated with intravenous administration of IS for 10 days. Results: In studies using VSMCs, IS loading tended to promote the calcification of VSMCs compared with controls (VSMCs cultured with a regular media), and P loading significantly promoted the calcification. No additive promotion of the calcification was observed with the combination of P and IS. Inflammaging maker genes were induced by P loading and IS further accelerated some of the marker genes. Aortic calcification was observed in adenine-induced renal injury mice with hyperphosphatemia, and the calcification was further accelerated when the mice were loaded with IS via a continuous intravenous route for 10 days using an infusion minipump. Markers of inflammaging were induced in the aortic tissue of this model. Conclusions: In the uremic condition, inflammaging was induced by P in parallel with vascular calcification progression, and it was suggested that loading with IS, a uremic substance, may enhance inflammaging and further promote vascular calcification.
원문(PDF)	PDF 원문보기

목록

위로가기