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논문분류	춘계학술대회 초록집
제목	Markers of Body Composition and Arterial Stiffness in Chronic Kidney Disease: from the KNOW-CKD Study
저자	Ju Young Lee
출판정보	2024; 2024(1):
키워드
초록	Objectives: Arterial stiffness measured by pulse wave velocity (PWV) is increased in chronic kidney disease (CKD) and is associated with the risk of high cardiovascular complication and mortality. Previous studies have shown that body composition is associated with arterial stiffness. However, there is relatively less data in CKD, and body composition and its clinical implication is different in CKD from the general population. The aim of this study is to investigate the association between different markers of body composition and arterial stiffness in CKD. Methods: This study analyzed 356 participants from the KNOW-CKD phase 2 cohort. They underwent anthropometry measurement and bioimpedance analysis. As markers of body composition, we used body mass index (BMI), waist circumferences (WST), waist-to-hip ratio (WHR), fat mass (FAT) and fat-free mass (FFM). Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV). Participants were divided into 3 groups according to their sex-specific fat-free mass (FFM) tertiles. Results: baPWV (cm/s) were lower in groups with higher FFM tertiles (1736±473, 1645±382 and 1520±347 for the 1st to 3rd tertiles of sex-specific FFM, respectively, P for trend<0.001). Among body composition markers, BMI, WST and FFM were inversely associated with baPWV in multivariate linear regression model (Table). When analyzing both BMI and FFM, or both WST and FFM at the same time, only FFM was significantly associated with baPWV. Conclusions: Rather than BMI, waist circumference and fat mass, fat-free mass was associated with arterial stiffness in CKD. The higher the fat-free mass, the lower the arterial stiffness.
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