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논문분류	춘계학술대회 초록집
제목	Kidney prognosis in patients with gross hematuria following COVID-19 vaccination
저자	Dal Sik Shin
출판정보	2024; 2024(1):
키워드
초록	Objectives: The coronavirus disease 2019 (COVID-19) vaccination can result in kidney-related complications. Abnormal urine tests, acute kidney injury, newly developed glomerulonephritis, and exacerbation of pre-existing kidney diseases following COVID-19 vaccination have been reported. This research aimed to understand renal complications following COVID-19 vaccination, specifically focusing on gross hematuria, and its impact on kidney disease. The coronavirus disease 2019 (COVID-19) vaccination can result in kidney-related complications. Abnormal urine tests, acute kidney injury, newly developed glomerulonephritis, and exacerbation of pre-existing kidney diseases following COVID-19 vaccination have been reported. This research aimed to understand renal complications following COVID-19 vaccination, specifically focusing on gross hematuria, and its impact on kidney disease. Methods: The retrospective questionnaire survey was performed on the patients visiting Soonchunhyang University Cheonan Hospital's nephrology outpatient department between January 1 and September 30, 2022. The questionnaire included vaccine type, dosage, vaccination date, and complications, including gross hematuria and other systemic symptoms. If gross hematuria occurred, its duration was recorded, and the laboratory parameter was followed up. Results: Primary findings were ten (3.6%) incidents of gross hematuria after COVID-19 vaccination, all of which were associated with mRNA vaccines, including: nine with mRNA-1273 (Moderna) and one with BNT162b2 (Pfizer-BioNTech). The average onset of gross hematuria after vaccination was 1.6 ± 0.8 days, lasting approximately 5.0 ± 4.8 days. Five of these patients had a prior diagnosis of immunoglobulin A nephropathy, two of whom experienced worsening proteinuria following gross hematuria event. Moreover, five new diagnoses emerged, including three with immunoglobulin A nephropathy, one with minimal change disease, and one with rhabdomyolysis. Conclusions: These results suggest that mRNA COVID-19 vaccines might instigate gross hematuria and play a role in the onset or exacerbation of glomerulonephritis. Thus, it is imperative for clinicians to monitor kidney functions closely for those with gross hematuria.
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