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논문분류	춘계학술대회 초록집
제목	Choroid plexus enlargement in patients with end-stage renal disease: implications for glymphatic system dysfunction
저자	Jiyae Yi
출판정보	2024; 2024(1):
키워드
초록	Objectives: The choroid plexus plays a role in eliminating detrimental metabolites from the brain as an integral component of the glymphatic system. The aim of this study was to investigate the alterations of the choroid plexus volumes in patients with end-stage renal disease (ESRD) compared to healthy controls. Methods: We prospectively enrolled 40 patients with ESRD and 42 healthy controls. They underwent brain magnetic resonance imaging scanning, especially with three dimensional T1-weighted imaging. We analyzed the choroid plexus volumes and compared them between the groups. We also evaluated the neuropsychological tests in patients with ESRD. We investigated the association between the choroid plexus volumes and neuropsychological tests. Results: There were significant differences of the choroid plexus volumes between the patients with ESRD and healthy controls. The choroid plexus volumes in patients with ESRD were higher than those in healthy controls (1.392 vs. 1.138%, p<0.001). The scores of word-list recognition in verbal memory were negatively correlated with the choroid plexus volumes in patients with ESRD (r=-0.428, p=0.006). Conclusions: We demonstrates the enlargement of the choroid plexus in patients with ESRD compared to healthy controls. This finding suggests that patients with ESRD have glymphatic system dysfunction, which may be related to their cognitive impairment.
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