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논문분류	춘계학술대회 초록집
제목	Improvement of brain function after hemodialysis in ESKD patients
저자	Euljo Jeong
출판정보	2024; 2024(1):
키워드
초록	Objectives: There have been numerous concerns about the neurologic impairment in ESKD patients with or without renal replacement treatments. Recently, several studies demonstrated that functional and structural deteriorated changes of brain in ESKD. However, there were lack of evidence of improvement of brain function after hemodialysis. Our study is aimed to explain the differences of brain function after hemodialysis. Methods: This prospective study was designed with 10-patient of ESKD, who had not been on renal replacement treatment previously and having no underlying neurological diseases. We examined each patient two times with diffusion-weighted MRI (dMRI), first at the time of hemodialysis and second 3-month after start of hemodialysis. The diffusion tensor imaging (DTI) tractography was reprocessed by q-sampling imaging (GQI) method and then, the resultant value of the quantitative anisotropy (GQ) were interpreted to detect trajectory of tracts within white matters. Results: We compared the results of differential tractography in pre-dialysis and post-dialysis. There were considerable changes with increased QA after dialysis, especially in cingulum, thalamic radiation, corpus callosum, and superior longitudinal fasciculus. Those structures are important due to their distinct structural roles of emotion, cognition, and so on. Not only for that, those have significant roles as functional connectivities in between other structures as well. Conclusions: Previous several studies had shown that impairment of brain functions in ESKD patients. In our study, improvement of functional and structural brain connectivities after hemodialysis was possibly explained with increased QA in several structures, such as in cingulum, thalamic radiation, corpus callosum, and superior longitudinal fasciculus.
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