대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Lithium-associated Kidney Failure: Predictors and Outcomes
저자	Emily Qian
출판정보	2024; 2024(1):
키워드
초록	Objectives: Lithium is a widely used agent for bipolar disorders and depression that has been rarely associated with chronic tubulointerstitial nephropathy following long-term use. Despite its rising incidence in recent years, little is known regarding patient characteristics and outcomes in those with lithium-associated kidney failure receiving kidney replacement therapy (KRT). Methods: A retrospective study evaluating the predictors and outcomes of patients with lithium-associated kidney failure receiving KRT was conducted using the Australian and New Zealand Dialysis and Transplant Registry (ANZDATA). Results: A total of 437 patients with lithium-associated kidney failure patients were compared to 1280 ANZDATA allocated controls at a ratio of 1:3. At KRT commencement, lithium patients were older (62±10 vs 58±15, p<0.001), more likely European (93% vs 68%, p<0.001), female (63% vs 40%, p<0.001) and living in a postcode with a higher socioeconomic status (SES) (p<0.001). Lithium patients were less comorbid, with lower rates of coronary artery disease (17% vs 37%, p<0.001), peripheral vascular disease (7% vs 25%, p<0.001), cerebrovascular disease (8% vs 14%, p=0.004) and diabetes mellitus (16% vs 47%, p<0.001). There were no differences between first KRT modality, although kidney transplantation and re-transplantation rates were lower (21% vs 27%, p=0.008; 0.2% vs 3%, p=0.001) and rejection rates were similar (21% vs 22%, p=0.85). There were shorter wait-times to first transplantation (20 months vs 29 months, p=0.02) in the lithium group. There were no survival differences regardless of KRT modality. Conclusions: Lithium-associated kidney failure is uncommon, and affects an older age group, females, those with European heritage, and a high SES. Despite having less comorbidities, there were no differences in survival regardless of KRT modality compared to the control population. Further directions include exploration of barriers to transplantation and future prediction models to identify those at high risk of kidney failure.
원문(PDF)	PDF 원문보기

목록

위로가기