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논문분류	춘계학술대회 초록집
제목	Understanding post-transplant anemia in kidney transplant recipients: insights from a Vietnamese cohort
저자	Nguyen Thu Ha
출판정보	2024; 2024(1):
키워드
초록	Objectives: This study aimed to investigate the primary risk factors associated with post-transplant anemia (PTA) in Vietnamese kidney transplant recipients (KTRs) over time Methods: Our study included 120 KTRs who underwent their first kidney transplant between 2021 and 2023, with average follow-up of 20.1±10.8 months, ranging from 1 to 36 months. We collected data on haemoglobin, serum creatinine, urinary tract infection and administering medications multiple times, including the initial outpatient check-up, every three months during the first year and every six months in the second and third years. Results: The incidence of anemia was 66.3% in early post-transplant phase, decreasing to 22.9% in late post-transplant period. Independent factors associated with anemia included hypertension, fasting blood glucose, triglycerides, blood level of tacrolimus, and dose of Mycophenolate mofetil (Table 1). Antiviral agents were found to reduce risk of anemia by 42%. Particular infections increased risk of anemia, such as urinary tract infection (HR: 2.19), cytomegalovirus (HR: 1.85), Epstein-Barr virus (HR: 2.31), while BK virus and JC virus reduced risk (HR: 0.53 and 0.72, respectively). Higher albumin and protein levels were associated with a lower incidence of anemia by 10% (Table 1). Using multiple Cox regression model, anemia (< 110 g/L) was linked to an 8.2 times greater risk for IKF among KTRs in comparison to individuals who did not have anemia (Tbale 2, Model 1). Moreover, the severity of anemia was associated with an 11.63-fold higher risk of IKF for moderate anemia and a 10.08-fold higher for severe anemia (Table 2, Model 2). Conclusions: Various independent transplant risk factors were associated with PTA, highlighting the importance of factors such as age, hypertension, glucose levels, and specific viral infections. Additionally, the study underscored a strong correlation between the severity of anemia and impaired kidney function, emphasizing the substantial impact of anemia on the recipients’ overall health.
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