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논문분류	춘계학술대회 초록집
제목	Change of podocyte-glomerular basement membrane interaction in nephrotic syndrome
저자	JAESEOK KIM
출판정보	2024; 2024(1):
키워드
초록	Objectives: Glomerular basement membrane (GBM) - podocyte interaction is important in podocyte stability. In our view, podocytes are believed to change their types of interaction with GBM under unfavorable conditions to preserve their stability. Here, we aimed to explore whether integrin (ITG) αVβ3, fibronectin (Fn), and urokinase-type plasminogen activator receptor (uPAR) were changed under nephrotic syndrome with human kidney tissue samples. Methods: We collected a total of 45 kidney tissues from the patients with trauma (control), minimal change disease (MCD), and membranous nephropathy (MN). We performed immunohistochemical staining for ITG β3, activated integrin (ACT-ITG) β3, Fn, and uPAR in those kidney tissue samples. Then, we compared the expressions of them between control, MCD, and MN. Results: The results showed that in MCD and MN, ITG β3 decreased, whereas ACT-ITG β3 increased more compared to those of control. Furthermore, Fn and uPAR also increased more in MCD and MN compared to those of control (Figure 1). When comparing control with nephrotic syndrome including MCD and MN, the nephrotic syndrome group showed less ITG β3 expression, whereas it showed more expressions of ACT-ITG β3, Fn, and uPAR (Figure 2). Conclusions: This study demonstrates that ITG αVβ3 is activated, while Fn and uPAR increase under nephrotic syndrome. We suggest that podocytes change their interaction with GBM under nephrotic syndrome.
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