대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Clinical implication of peri-renal fat on the kidney function in patients with early diabetic kidney disease
저자	Da Woon Kim
출판정보	2024; 2024(1):
키워드
초록	Objectives: To investigate 1) correlation between peri-renal fat thickness (PRFT) and baseline clinical characteristics, 2) differences of PRFT among three groups divided by estimated glomerular filtration rate (eGFR) slope (stable [> -1 ml/min/1.73m2/year], progressive [-3 to -1 ml/min/1.73m2/year], rapidly progressive [< -3 ml/min/1.73m2/year]), 3) prognostic effect of PRFT on 5-year major adverse kidney events (MAKE) defined as 30% reduction of eGFR from baseline or start of kidney replacement therapy. Methods: Subjects with type 2 diabetes (T2D) between January 2010 and December 2015 at a single university-affiliated hospital were retrospectively reviewed. The inclusion criteria were as follows; 1) who underwent computed tomography scan of abdomen before or after 1 year from start of out-patient care, 2) who underwent kidney function tests more than 3 times during 5-year of follow-up period, 3) whose serum creatinine < 1.2 mg/dL or eGFR > 60 ml/min/1.73m2 at start of out-patient care. We measured PRFT as maximal distances between posterior boundary of each kidney and inner boundary of the abdominal wall on a slice passing through renal vein. Results: Duration of T2D was 3 (0-10) years. Age (r = 0.19, P = 0.009), body mass index (BMI, r=0.47, P<0.001) and baseline eGFR (r = -0.21, P = 0.004) showed correlation with PRFT. PRFT showed no difference among eGFR slope groups (11.41 [7.08-20.51]mm in stable group, 12.03 [2.64-16.16)] mm in progressive group, 11.01 [5.95-17.12]mm in rapidly progressive group, P = 0.190). During 5-year of follow-up period, MAKE occurred in 22 (12.0%) of total subjects. PRFT was not a prognostic factor for occurrence of 5-year MAKE (HR, 0.98 [95% CI, 0.94-1.03], P=0.427). Conclusions: In patients with early diabetic kidney disease, PRFT at baseline was positively correlated with age, BMI and negatively correlated with eGFR. However, PRFT was not related to the change of eGFR for 5 years and 5-year MAKE.
원문(PDF)	PDF 원문보기

목록

위로가기