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논문분류	춘계학술대회 초록집
제목	The Incidence, Associative Factors, and Outcomes of Acute Kidney Injury in Intensive Care Units in Malaysia
저자	Kuan Yee Lim
출판정보	2024; 2024(1):
키워드
초록	Objectives: Acute kidney injury (AKI) is common among hospitalized patients, even more in those who require intensive care unit (ICU) admission. AKI in hospitalized patients results in a longer duration of hospital stay, dialysis dependence, and significantly higher mortality especially among the critically ill patients in short-term, and an increased risk of progression to chronic kidney disease (CKD) and end-stage renal disease (ESRD) in long-term. Nevertheless, literature regarding AKI in ICU is scarce in Malaysia and Southeast Asia. Methods: We conducted a prospective observational study of patients who were admitted to the ICU. We aimed to determine the incidence and associative factors of AKI among ICU patients as well as to compare the outcomes of those with and without AKI. Results: 190 patients were admitted to the ICU from October to December 2023. Among them, 65.3% were male, with a mean age of 56±16 years. 50% of ICU patients developed AKI. Among them, 39% had stage 3 AKI. The associative factors of AKI in ICU patients include age, sex, body mass index, hypertension, diabetes mellitus, dyslipidaemia, baseline CKD, previous episode of AKI, recent hospitalization, nephrotoxic medication, number of vasopressors required, and high sequential organ failure assessment (SOFA) score, however, SOFA score is the only statistically significant predictive factor with a p-value of <0.001 as shown in Table 1. SOFA score of 3.5 and more is able to predict AKI with a sensitivity of 84.2% and specificity of 57.9% as shown in Figure 1. In terms of in-hospital outcomes, ICU patients with AKI have longer durations of vasopressor and mechanical ventilation requirements, longer ICU stay, and higher mortality. Conclusions: The incidence of AKI in ICU is high which results in poorer in-hospital outcomes. SOFA score of 3.5 and more is able to predict AKI in ICU with good sensitivity and specificity.
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