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논문분류	춘계학술대회 초록집
제목	Exposure of PM2.5 and its constituents are associated with chronic kidney disease
저자	Tai-Shuan Lai
출판정보	2024; 2024(1):
키워드
초록	Objectives: The connection between exposure to fine particulate matter (PM2.5) and chronic kidney disease (CKD) has been observed, but remains a topic of debate. The impact of PM2.5's individual and combined components on CKD has been underexplored. Our study aims to examine the relationship between long-term exposure to 15 key PM2.5 components and CKD. Methods: We included 23,820 participants from seven regions in Taiwan in our study. The Taiwan Environmental Protection Administration provided hourly PM2.5 concentration readings from January 2006 to December 2008. We employed a refined kriging model to estimate each participant's long-term exposure to PM2.5 at their residence. We also utilized spherical spatial models to calculate residential PM2.5 levels. The 15 analyzed PM2.5 constituents were elemental carbon, organic carbon, sulfate, ammonium, nitrate, barium, iron, copper, manganese, zinc, antimony, molybdenum, cadmium, lead, and nickel. CKD was identified using the estimated glomerular filtration rate (eGFR), with an eGFR below 60 ml/min/1.73 m^2 indicating CKD. Results: After removing participants with incomplete renal data, those in CKD stage 5, deceased before 2008, or residing outside Taiwan's main island, 12,250 participants were included in the analysis. Adjusting for factors such as age, sex, body mass index, smoking habits, diabetes, heart disease, and serum uric acid levels, we found a significant negative correlation between PM2.5 levels and eGFR (beta±SE: -0.16±0.019, P < 0.0001) in Table 1. Almost all PM2.5 components showed a strong link with eGFR, except for ammonium and copper. When evaluating the impact of all PM2.5 components together, elemental carbon, organic carbon, and antimony were identified as having the most significant effect on eGFR levels (Table 2). Conclusions: Our findings confirm a significant association between PM2.5 exposure and CKD, highlighting elemental carbon, organic carbon, and antimony as key contributors to this relationship.
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